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65l텔레그램Dbchance❤️➡️오피디비판매}_

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작성자 호철 조회 1회 작성일 25-04-30 15:29

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65l텔레그램Dbchance❤️➡️오피디비판매}_ 유한양행은 29일 (현지 시각) 미국 시카고에서 개최된 미국암연구학회(AACR 2025) 연례 학술대회에서 자사의 항암 신약 파이프라인인 표적항암제 YH42946(JIN-A04) 및 면역항암제 YH32364 (ABL104)의 전임상 연구 결과를 발표했다고 밝혔다.해당 결과는 이달 25일부터 30일(현지시간)까지 진행된 AACR 2025에서 포스터 발표 형식으로 공개됐다. 관련 초록은 지난 3월 25일 학회 홈페이지를 통해 게재된 바 있다.YH42946은 HER2 (Human Epidermal Growth Factor Receptor 2) 및 EGFR (Epidermal Growth Factor Receptor) 변이를 표적으로 하는 티로신 키나제 억제제 (Tyrosine Kinase Inhibitor·TKI) 계열의 항암제로, HER2(인간 상피세포 성장인자 수용체 2형) 엑손 20 삽입을 포함한 다양한 돌연변이와 HER2 증폭과 발현, 그리고 EGFR 엑손20 삽입 변이에 대해서도 우수한 항종양 활성을 보였다.특히 비소세포폐암 환자에서의 HER2 및 EGFR(표피 성장인자 수용체) 엑손 20 삽입 변이는 기존의 TKI 치료에 잘 반응하지 않기 때문에, 환자들이 사용할 수 있는 치료제가 매우 제한적이다.이번 학회에서는 연세암병원 조병철 교수 연구팀이 YH42946의 비소세포폐암의 EGFR 엑손 20 삽입 변이에 대한 항암효과를 환자유래 세포 (PDC)를 포함해 다양한 세포실험 기반 주요 전임상 결과를 발표했다. 그 결과, YH42946은 기존의 HER2 엑손 20 삽입 변이에 대한 활성뿐만 아니라, EGFR 엑손 20 삽입변이에 대해서도 넓은 범위에서 억제 효과가 확인됐다.YH42946은 유한양행이 2023년 제이인츠바이오로부터 기술이전 받은 신약 후보물질로, 현재 HER2 및 EGFR 유전자 변이를 동반한 국소 진행성 또는 전이성 고형암 환자를 대상으로 글로벌 임상 1/2상이 진행 중이다.한편, YH32364는 유한양행과 에이비엘바이오가 공동 연구를 통해 개발한 이중 작용 면역항암제로, EGFR을 발현하는 종양세포에 특이적으로 결합하여 성장 신호를 차단하는 동시에, T세포 활성 수용체인 4-1BB를 자극하여 면역세포의 항암 활성을 증가시키는 작용 기전을 보인다.세포기반시험(in vitro) 결과, YH32364는 EGFR을 발현하면서 KRAS 변이를 가진 폐암, 대장암 세포에서 경쟁약물대비 T세포 활성화를 비롯한 강력한 항종양 효과를 나타내었다. 두경부암 종양세포에서는 anti-PD1 항체와의

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